Avaliação da eficácia antimicrobiana do extrato de própolis verde em bactérias causadoras de infecções respiratórias
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014
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Resumo: Esta pesquisa explora a eficácia da própolis como alternativa antimicrobiana
natural. Devido à sua complexa composição química, tem menor probabilidade de
levar ao desenvolvimento de cepas resistentes, oferecendo uma opção mais segura
e econômica. Avaliou-se cinco subtipos desta resina (verde, amarelo, preto, marrom
e vermelho) contra estirpes bacterianas resistentes: Staphylococcus aureus,
Streptococcus pyogenes e Klebsiella Pneumoniae Carbapenemase (KPC). Foram
realizados dois testes: um com alta densidade bacteriana e outro com densidade
moderada, simulando condições realistas de infecção. Discos de papel impregnados
com os extratos foram aplicados nas placas e, após 24 horas, alguns deles
apresentaram halo de inibição de crescimento. Adicionalmente, um refratômetro foi
utilizado para medir a concentração de açúcares em sprays a base deste princípio
ativo, avaliando seu impacto na eficácia terapêutica. Com base nos melhores
resultados, foi desenvolvido um spray em laboratório, sem adição de açúcares.
Abstract: This research explores the effectiveness of propolis as a natural antimicrobial alternative. Due to its complex chemical composition, it is less likely to lead to the development of resistant strains, offering a safer and more economical option. Five subtypes of this resin (green, yellow, black, brown and red) were evaluated against resistant bacterial strains: Staphylococcus aureus, Streptococcus pyogenes and Klebsiella Pneumoniae Carbapenemase (KPC). Two tests were carried out: one with high bacterial density and the other with moderate density, simulating realistic infection conditions. Paper discs impregnated with the extracts were applied to the plates and, after 24 hours, some of them showed a halo of growth inhibition. Additionally, a refractometer was used to measure the concentration of sugars in sprays based on this active ingredient, evaluating its impact on therapeutic efficacy. Based on the best results, a spray was developed in the laboratory, without added sugars.
Abstract: This research explores the effectiveness of propolis as a natural antimicrobial alternative. Due to its complex chemical composition, it is less likely to lead to the development of resistant strains, offering a safer and more economical option. Five subtypes of this resin (green, yellow, black, brown and red) were evaluated against resistant bacterial strains: Staphylococcus aureus, Streptococcus pyogenes and Klebsiella Pneumoniae Carbapenemase (KPC). Two tests were carried out: one with high bacterial density and the other with moderate density, simulating realistic infection conditions. Paper discs impregnated with the extracts were applied to the plates and, after 24 hours, some of them showed a halo of growth inhibition. Additionally, a refractometer was used to measure the concentration of sugars in sprays based on this active ingredient, evaluating its impact on therapeutic efficacy. Based on the best results, a spray was developed in the laboratory, without added sugars.
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FERREIRA, Ketlyn Nunes; NASCIMENTO, Yasmin de Brito. Avaliação da eficácia antimicrobiana do extrato de própolis verde em bactérias causadoras de infecções respiratórias. 2024.Trabalho de Conclusão de Curso (Curso Técnico em Química) – Etec Júlio de Mesquita, Santo André, 2024.
